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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating β-catenin

Fig. 3

The expression of PCBP1 with respect to metastasis. A Volcano plot of DEGs in RNA-seq. B GO analysis showing the top gene functions that were mostly different among the PCBP1 high and low expression groups based on RNA-seq. C Heatmap showing the EMT-related DEGs identified by RNA-seq. D KEGG pathway enrichment analysis of DEGs. E The heatmap shows differential genes in WNT signalling pathways in A549 RNA‐seq data. F GSEA validated the enhanced activity of “Epithelial-Mesenchymal Transition”. G Validation of 22 selected genes by qPCR in PCBP1 knockdown and overexpression cells

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Journal of Translational Medicine

ISSN: 1479-5876

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