Fig. 7

IGF2BP1/ERRα axis regulated in vitro and in vivo Dox sensitivity of OS cells. Cell proliferation of sh-Control and sh-IGF2BP1 MG-63/Dox (a) or HSO/Dox (b) cells; Dox sensitivity of sh-Control and sh-IGF2BP1 MG-63/Dox (c) or HSO/Dox (d) cells treated with Dox for 24 h; sh-Control and sh-IGF2BP1 MG-63/Dox (e) or HSO/Dox (f) cells were treated with 1 μM XCT-790 and 1 μM Dox for 24 h; g xenografts of sh-Control and sh-IGF2BP1 MG-63/Dox cells were treated with Dox combined with or without XCT-790. The tumor growth curves were recorded every three days; tumor volume (h) and tumor weight (i) of xenografts for each group at the end of the experiment. Data are presented as means ± SD from three independent experiments. ^**p < 0.01 by Student’s t test