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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: IGF2BP1-regulated expression of ERRα is involved in metabolic reprogramming of chemotherapy resistant osteosarcoma cells

Fig. 6

IGF2BP1/ERRα axis regulated metabolic reprogramming of Dox-resistant OS cells. The relative levels of ATP generation (a), consumption of glucose (b), and production of lactate (c) in sh-Control and sh-IGF2BP1 cells; the levels of OCR in sh-Control and sh-IGF2BP1 MG-63/Dox (d) or HOS/Dox (e) cells were determined by extracellular flux analysis. f The protein expression of ERRα in sh-Control or sh-IGF2BP1 cells transfected with vector control or pcDNA/ERRα for 24 h; the ATP generation (g), consumption of glucose (h), and production of lactate (i) in sh-Control and sh-IGF2BP1 MG-63/Dox cell transfected with empty vector or pcDNA/ERRα for 24 h. Data are presented as means ± SD from three independent experiments. Each experiment was performed in six replicates for OCR or ECAR analysis. **p < 0.01, NS, no significant, by Student’s t test

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