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Table 1 Participant characteristics

From: Association between postoperative radiotherapy for young-onset head and neck cancer and long-term risk of second primary malignancy: a population-based study

Variables

Totala, no. (%)

PORT, .no (%)

No PORT, .no. (%)

P value

Total No. of events

2771

1042

1729

 

Median follow-up time, months (IQR)

217(137, 311)

197 (125, 269)

235 (146, 339)

 < 0.001

Age at diagnosis, year

   

 < 0.001

  0–35

641(23.1)

183(28.5)

458(71.5)

 

  > 35

2130(76.9)

859(40.3)

1271(59.7)

 

 Race

   

 < 0.001

 White

2417(87.2)

867(35.9)

1550(64.1)

 

 Black

197(7.1)

114(57.9)

83(42.1)

 

Other‡

131(4.7)

57(43.5)

74(56.5)

 

Unknown

26(0.9)

4(15.4)

22(84.6)

 

Sex

   

0.772

 Female

740(26.7)

275(37.2)

465(62.8)

 

 Male

2031(73.3)

767(37.8)

1264(62.2)

 

Year of diagnosis

   

 < 0.001

 1975–2000

1871(67.5)

646(34.5)

1225(65.5)

 

 2001–2018

900(32.5)

396(44.0)

504(56.0)

 

Site of index HNSCC

   

 < 0.001

 Oral cavity

1876(67.7)

420(22.4)

1456(77.6)

 

 Oropharynx

383(13.8)

323(84.3)

60(15.7)

 

 Larynx

490(17.7)

281(57.3)

209(42.7)

 

Hypopharynx

22(0.8)

18(81.8)

4(18.2)

 

Stage of index HNSCC

    

 Localized

1681(60.7)

320(19.0)

1361(81.0)

 < 0.001

 Regional

949(34.2)

669(70.5)

280(29.5)

 

 Unknown

141(5.1)

53(37.6)

88(62.4)

 

Development of SPMs

   

0.322

 No

2177(78.6)

829(38.1)

1348(61.9)

 

 Yes

594(21.4)

213(35.9)

381(64.1)

 

Median follow-up time at event (any SPMs), months (IQR)

173(111, 253)

166(47.7)

182(52.3)

 < 0.001

  1. PORT postoperative radiotherapy, HNSCC head and neck squamous cell carcinoma, SPMs second primary malignancies, IQR interquartile range
  2. aAfter exclusion based on the minimum latency span, the characteristics of 5 year survivors of index young-onset HNSCC were reported
  3. bOther races in SEER database included Asian/Pacific Islander, American Indian and Alaska Native