Modulation of hepatic stellate cells by Mutaflor® probiotic in non-alcoholic fatty liver disease management

Table 3 Spearman’s correlation between the RQ of the selected mRNAs, miRNA, LncRNA, effector protein concentration and HSCs activation

Biomarker		FOXA2 mRNA	TEAD2 mRNA	LATS2 mRNA	miR-650	RPARP-AS1 LncRNA	IL6	TGF-β	α-SMA H-score
FOXA2 mRNA	r	1	0.77	− 0.75	0.74	− 0.74	0.75	0.75	o.74
FOXA2 mRNA	Sig		< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a
TEAD2 mRNA	r	0.77	1	− 0.67	0.84	− 0.64	0.89	0.87	0.85
TEAD2 mRNA	Sig	< 0.01^a		< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a
LATS2 mRNA	r	− 0.75	− 0.67	1	− 0.72	0.82	− 0.7	− 0.74	− 0.71
LATS2 mRNA	Sig	< 0.01^a	< 0.01^a		< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a
miR-650	r	0.74	0.84	− 0.72	1	− 0.74	0.85	0.9	0.79
miR-650	Sig	< 0.01^a	< 0.01^a	< 0.01^a		< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a
RPARP-AS1 LncRNA	r	− 0.75	− 0.64	0.82	− 0.74	1	− 0.71	− 0.74	− 0.74
RPARP-AS1 LncRNA	Sig	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a		< 0.01^a	< 0.01^a	< 0.01^a
IL6	r	0.75	0.89	− 0.7	0.85	− 0.71	1	0.95	0.84
IL6	Sig	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a		< 0.01^a	< 0.01^a
TGF-β	r	0.75	0.87	− 0.74	0.9	− 0.74	0.95	1	0.8
TGF-β	Sig	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a	< 0.01^a		< 0.01^a

ISSN: 1479-5876