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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Modulation of hepatic stellate cells by MutaflorĀ® probiotic in non-alcoholic fatty liver disease management

Fig. 6

A Immunohistochemical staining (IHC) of Ī±-SMA and B LATS 2 in liver sections from separate groups as indicated in the figures (Magnifications: Ɨ100). C Statistical difference in Ī±-SMA and LATS2 H-score among study groups. IHC assays demonstrated that liver tissue of NASH rats had more Ī±-SMA-positive cells were localized in areas with inflammatory cells and areas with remarkable perisinusoidal fibrosis. The expression of Ī±-SMA showed a significant increase in 12-week NASH group, 9-week NASH group and Broth group when compared with the Control group, However, in 12-week Treated and 9-week Treated groups, there was an evident decrease in the Ī±-SMA expression. IHC assays of LATS2 were markedly decreased in 12-week NASH, 9-week NASH and Broth groups when compared to the Control group. However, 12-week Treated and 9-week Treated groups showed a significant increase in LATS2 expression when compared to the 12-week NASH group

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