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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38/Elk-1 pathway

Fig. 5

Asprosin inhibits the development of atherosclerosis. A–G ApoE−/− mice were fed a Western diet for 12 weeks and simultaneously underwent tail vein injection of LV-Mock or LV-Asprosin once three weeks (n = 15 mice per group). A Comparison of body weight gain (n = 15 mice per group). B Western blot analysis of asprosin protein expression in the aortas (n = 5 mice per group). C Representative images of aortic arch regions with white plaques (green arrows). D Enface analysis of atherosclerotic lesion area using Oil Red O staining (n = 5 mice per group). E–G The aortic valve cross-sections were stained with HE, Oil Red O and Masson Trichrome to evaluate lesion area, lipid deposition and collagen content, respectively (n = 10 mice per group). The results are shown as the mean ± SD. **P < 0.01, ***P < 0.001. NS indicates not significant

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