Sex hormones and physical function among the Chinese oldest-old and centenarian women

Zhu, Qiao; Ping, Ping; Zhang, Pei; Ning, Chaoxue; Zhao, Yali; Yao, Yao; Li, Xiubing; Fu, Shihui

doi:10.1186/s12967-022-03539-9

Journal of Translational Medicine

Table 5 Multivariate linear regression analyses with ADL in all the participants

From: Sex hormones and physical function among the Chinese oldest-old and centenarian women

Models	Variables	Oldest-old women		Centenarian women		All
Models	Variables	Beta (95% confidence interval)	P	Beta (95% confidence interval)	P	Beta (95% confidence interval)	P
Model 1^a	E2 (pmol/L)^d	− 0.03 (− 0.15, 0.10)	0.705	− 0.23 (− 0.29, − 0.17)	< 0.001	− 0.30 (− 0.35, − 0.24)	< 0.001
	T (nmol/L)^d	− 0.01 (− 0.82, 0.81)	0.985	− 1.84 (− 3.16, − 0.53)	0.006	− 0.18 (− 0.99, 0.63)	0.667
	E2/T^d	0.01 (− 0.01, 0.02)	0.527	0.00 (− 0.01, 0.01)	0.917	0.00 (− 0.01, 0.01)	0.761
	FSH (mIU/mL)^d	0.00 (− 0.07, 0.07)	0.985	− 0.08 (− 0.16, 0.01)	0.096	− 0.05 (− 0.11, 0.02)	0.173
	LH (mIU/mL)^d	− 0.11 (− 0.24, 0.03)	0.135	− 0.09 (− 0.26, 0.09)	0.317	− 0.12 (− 0.25, 0.01)	0.071
Model 2^b	E2 (pmol/L)^d	− 0.01 (− 0.14, 0.12)	0.932	− 0.23 (− 0.30, − 0.17)	< 0.001	− 0.30 (− 0.35, − 0.24)	< 0.001
	T (nmol/L)^d	− 0.11 (− 0.95, 0.73)	0.797	− 1.85 (− 3.17, − 0.53)	0.006	− 0.14 (− 0.95, 0.67)	0.735
	E2/T^d	0.00 (− 0.01, 0.02)	0.641	0.00 (− 0.01, 0.01)	0.871	0.00 (− 0.01, 0.01)	0.751
	FSH (mIU/mL)^d	0.00 (− 0.07, 0.07)	0.971	− 0.08 (− 0.17, 0.01)	0.087	− 0.05 (− 0.11, 0.02)	0.167
	LH (mIU/mL)^d	− 0.11 (− 0.24, 0.03)	0.139	− 0.09 (− 0.26, 0.09)	0.338	− 0.12 (− 0.25, 0.01)	0.069
Model 3^c	E2 (pmol/L)^d	− 0.01 (− 0.14, 0.12)	0.875	− 0.23 (− 0.30, − 0.17)	< 0.001	− 0.22 (− 0.28, − 0.17)	< 0.001
	T (nmol/L)^d	− 0.04 (− 0.87,0.79)	0.924	− 1.83 (− 3.15, − 0.51)	0.007	− 0.37 (− 1.14, 0.40)	0.345
	E2/T^d	0.01 (− 0.01, 0.02)	0.557	0.00 (− 0.01, 0.01)	0.869	0.00 (− 0.01, 0.01)	0.389
	FSH (mIU/mL)^d	0.00 (− 0.07, 0.07)	0.947	− 0.08 (− 0.16, 0.01)	0.092	− 0.05 (− 0.11, 0.01)	0.095
	LH (mIU/mL)^d	− 0.09 (− 0.23, 0.05)	0.210	− 0.09 (− 0.26, 0.09)	0.327	− 0.08 (− 0.20, 0.05)	0.218

ADL activity of daily living; E2 estradiol; E2/T estradiol/testosterone; FSH follicle-stimulating hormone; LH luteinizing hormone; T testosterone
^aMultivariate linear regression analyses were used with E2, T, E2/T, FSH and LH as independent variables and with ADL as dependent variable
^bMultivariate linear regression analyses were used with ethnicity, education, smoker, drinker, E2, T, E2/T, FSH and LH as independent variables and with ADL as dependent variable
^cMultivariate linear regression analyses were used with age, ethnicity, education, smoker, drinker, E2, T, E2/T, FSH and LH as independent variables and with ADL as dependent variable
^dPer 1 unit increase

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ISSN: 1479-5876

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