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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors

Fig. 4

Forced TNFR2 expression sensitizes BRAFV600E+ melanoma to solTNF-induced resistance to MAPKi. TNFR2 knockin (KI) SK-Mel-28 variant was generated. TNFR profile was evaluated by A flow cytometry and B immunofluorescence microscopy. C Unmodified “wild-type” (WT) and stably-transfected TNFR2.+ SK-Mel-28 cells (TNFR2 KI) were cultured in the presence or absence of solTNF and tested for their sensitivity to BRAFi and MEKi-mediated killing. Data shown represent mean values of triplicate tests and whiskers represent standard error. *p ≤ 0.05

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