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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis

Fig. 5

Serpin E1 overexpression promotes the growth, migration, and invasion and inhibits the apoptosis of gastric cancer cells. A Growth curve of three gastric cancer cells by a CCK-8 assay upon Serpin E1 overexpression. **P < 0.01 and ****P < 0.0001 vs. Empty. B Colony formation assays of three gastric cancer cells upon Serpin E1 overexpression. The bar graph shows the quantitation of the colony number of cancer cells. *P < 0.05 and **P < 0.01. C Transwell migration and Matrigel invasion assays of three gastric cancer cells upon Serpin E1 overexpression. The bar graph shows the quantification of migrated or invaded cells. Scale bar = 200 μm. D The apoptosis of three gastric cancer cells induced by As2O3 upon Serpin E1 overexpression was examined by flow cytometry analysis. The bar graph shows the apoptosis rate of cancer cells at the indicated concentration of As2O3. *P < 0.05, ***P < 0.001, and **** P < 0.0001

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