Table 1 Influence of the location on the prognosis of acral melanoma

Gavillero A

Retrospective study

n = 285 (SSM and NM on the lower limb)

Foot vs. Leg

Multifactorial and univariate analyses confirmed the foot location as an independent prognostic factor associated with reduced melanoma-specific survival (HR of 2.3 and 2.7, respectively)

[28]

Martina Sanlorenzo

Retrospective study

n = 1671 (Total);

n = 327 (Foot)

Foot vs. Leg

Multifactorial and univariate analyses confirmed the foot site as a negative independent prognostic factor for disease-specific survival (HR of 2.53 and 1.52 respectively)

[22]

Xiaoting Wei

Multi-center retrospective study

n = 1157;

n = 792 (Soles);

n = 95 (Palms);

n = 270 (Nail beds)

Sole vs. Nail bed vs. Palm

The 10-year survival rates were 32.8%, 60.4%. and 48.9% for sole, palm, and nail bed groups, respectively. The median MSS of patients in the sole group was only 65.0 m, significantly shorter than in the nail bed (112.0 m) and palm group (NR) (p = 0.0053)

[29]