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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases

Fig. 2

Glycolytic pathway activity is enhanced in groups with higher CRS grades. A–C Relative signaling pathway activity score was calculated based on GSVA analysis. JAK-STAT, Interleukin, and glycolysis signaling pathways showed higher activity in the high CRS grade group. The x-axis represents different CRS grades. D Correlation between PFKFB4 gene expression and genes involved in glycolysis signaling pathway. Correlation coefficient and p-values are listed at the up-left corner. The x-axis represents relative PFKFB4 gene expression. The y-axis shows the expression of genes that are involved in the glycolysis pathway

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