Fig. 7

RGD-Exo-circDIDO1 efficiently inhibits GC growth in mice. A PBS, RGD-Exo, and RGD-Exo-circDIDO1 were intravenously injected into nude mice bearing subcutaneous xenograft tumors. At 28 days after treatment, the mice were sacrificed and the volume and weight of tumors were recorded. Data are shown as mean ± SD (n = 5 for each group, **P < 0.01). B HE, Ki-67 and TUNEL staining of xenograft tumor tissues treated with PBS, RGD-Exo, and RGD-Exo-circDIDO1. Scale bars = 100 μm. C qRT-PCR assays were used to examine miR-1307-3p and SOCS2 expression in GC cells and tissues treated with PBS, RGD-Exo, and RGD-Exo-circDIDO1. Data are shown as mean ± SD (n = 3, **P < 0.01, *P < 0.05). D Western blotting analyses of treated GC cells and tumor tissues. E Histopathological analyses of heart, liver, spleen, lung and kidney sections stained with HE. Scale bars = 60 μm. F Blood biochemistry for liver function markers: ALT, AST and ALP and kidney function markers: BUN and CRE. Data are shown as mean ± SD (n = 5 for each group)