Fig. 3

SOCS2 is a target of miR-1307-3p. A ENCORI Pan-Cancer Analysis Platform was used to analyze the correlation of miR-1307-3p and SOCS2 in 372 cases of STAD patients. B qRT-PCR analyses of the expression of SOCS2 and circDIDO1 in tumor tissues of 17 GC patients. C Luciferase reporter assay in GC cells co-transfected with wide-type (WT) or mutant (MUT) SOCS2 plasmid together with miR-1307-3p mimic or NC. D The relative level of SOCS2 expression after transfection with circDIDO1 in GC cells. E The relative level of SOCS2 expression in control and miR-1307-3p overexpressing GC cells. F–I Cell growth curve, colony formation, transwell migration, and matrigel invasion assays for control and SOCS2 overexpressing GC cells. Data are shown as mean ± SD (n = 3, **P < 0.01, *P < 0.05). Scale bars = 100 μm