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Figure1 | Journal of Translational Medicine

Figure1

From: Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway to regulate colorectal cancer progression

Figure1

FOXS1 is overexpressed in primary colorectal cancer (CRC). A The FOXS1 mRNA was significantly upregulated in CRC compared with adjacent normal tissues (P < 0.01). B Kaplan–Meier analysis indicated that CRC patients with high FOXS1 expression had significantly worse OS than patients with low FOXS1 expression (P < 0.01). C The protein levels of FOXS1 in 8 pairs of colorectal cancer and paracancer tissues. D The expression of FOXS1 protein was distributed in the cytoplasm and nucleus of CRC tumor tissues; a and e, FOXS1 was not detected in normal colorectal tissues; b and f, representative images of weak FOXS1 staining in CRC tissues; c and g, representative images of moderate FOXS1 staining in CRC tissues; d and h, representative images of strong FOXS1 staining in CRC tissues; a, b, c, and d, original magnification ×100 (scale bar = 100 μM); e, f, g, and h, ×400. E The higher expression of FOXS1 was related to shorter OS in CRC patients. F Western blot and qPCR analysis of FOXS1 expression in various CRC cell lines and normal colon epithelial cell line NCM460

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