Table 3 Multivariate cox regression analysis of prognostic factors associated with OS and DFS
Variables | Multivariate analysis | |
|---|---|---|
Hazard ratio (95% CI) | P value | |
OS | ||
Tumor differentiation | ||
Well and moderate versus poor | 0.278 (0.147, 0.529) | 0.000* |
Perineural invasion | ||
Yes versus no | 2.323 (1.228, 4.395) | 0.010* |
Adjuvant therapy | ||
Yes versus no | 0.262 (0.133, 0.516) | 0.000* |
DFS | ||
Depth of invasion | ||
T3 versus Tis–T2 | 4.882 (1.166, 20.442) | 0.03* |
T4 versus Tis–T2 | 7.623 (1.665, 34.892) | 0.009* |
Lymph node metastasis | ||
Yes versus no | 2.780 (1.484, 5.209) | 0.001* |
Serum glutamine | ||
≤ 392.83 versus > 392.83 | 2.021 (1.128, 3.622) | 0.018* |