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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Glutamine deficiency promotes recurrence and metastasis in colorectal cancer through enhancing epithelial–mesenchymal transition

Fig. 4

The different mRNA and protein expression of TFs in CRC cells treated with different glutamine concentration. A The mRNA expression of zeb1 and snail 2 were increased in 0.5mM glutamine defiency group in SW480 cells. B The results showed that the zeb1 mRNA expression in the 0.5 mM and 1.0 mM glutamine deficiency groups were significantly increased compared with the normal glutamine group in DLD1 cells. Zeb2 mRNA expression was also upregulated in the 0.5 mM glutamine deficiency group in DLD1 cells. C Protein expression of TFs in CRC cells treated with different glutamine concentration. D The results of western blot showed that zeb1 and Zeb2 in glutamine deficiency groups were significantly increased compared with the normal glutamine group in SW480 cells. Zeb2 in glutamine deficiency groups were significantly increased compared with the normal glutamine group in DLD1 cells. *P < 0.05, compared with control group

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