Table 3 Univariable and multivariable Cox regression analysis of the novel immune checkpoints-based signature and overall survival in independent cohort
| Â | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
Variable | HR | 95%CI | P value | HR | 95%CI | P value |
Age | ||||||
  ≥ 60 or < 60 | 1.0729 | 1.0205–1.1280 | 0.0060 | 1.1151 | 1.0474–1.1871 | 0.0006 |
Sex | ||||||
 Male or female | 1.1943 | 0.5473–2.6062 | 0.6556 | 1.0806 | 0.4709–2.4796 | 0.8548 |
Smoking history | ||||||
 Yes or no | 1.0080 | 0.4618–2.2002 | 0.9841 | 0.6269 | 0.2693–1.4593 | 0.2787 |
T stage | ||||||
 1, 2, 3 or 4 | 1.2456 | 0.8004–1.9384 | 0.3305 | 0.8782 | 0.4234–1.8216 | 0.7272 |
Lymphatic metastasis | ||||||
 Yes or no | 4.2542 | 1.8319–9.8794 | 0.0008 | 3.4297 | 1.0293–11.4279 | 0.0447 |
TNM stage | ||||||
 I, II, III or IV | 2.4857 | 1.4564–4.2426 | 0.0060 | 1.8899 | 0.6834–5.2266 | 0.2200 |
Risk score | ||||||
 High or low | 3.0210 | 1.4103–6.4713 | 0.0044 | 3.1143 | 1.3997–6.9293 | 0.0054 |