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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model

Fig. 1

sCCR2 regulates the pain threshold in MIA rat. A A schematic diagram of soluble CCR2 E3 (sCCR2-E3) and soluble CCR2 full (sCCR2-Full) vector map. B A schematic diagram of the experimental protocols used demonstrating sCCR2-Full and sCCR2-E3 gene therapy in OA (N = 3). C Nociceptive testing was performed using a dynamic plantar esthesiometer, an automated version of the von Frey hair assessment procedure (PWL and PWT). D Weight bearing was performed using an in capacitance meter. Representative results from one of three independent experiments are shown regarding PWL, PWT and weight bearing for each group. The data are representative of at least three independent experiments. The data show the mean ± SEM of three independent experiments. (*p < 0.05, ** p < 0.01, *** p < 0.001)

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