Fig. 5

Functional interaction networks. A Network of amplified genes found through multigene panel sequencing. B Functional network involving only mutated genes. C HIF1a signaling network involving miRNA targets. D Multi-level network considering both miRNA targets and gene variations. Circles are labeled with gene names, rectangles represent pathways, while diamonds the miRNAs. Different colors of the circles indicate if the genes are amplified (green), mutated (blue), targeted by miRNA (pink) or targeted and/or amplified (pink and green). Dashed lines indicate correlation between miRNAs and their targets, while full lines indicate gene connections to specific signalings