Fig. 3

Genomic rearrangements of NENs. A Circos plot showing aCGH-derived genomic rearrangements (middle ring) and fusion transcripts (inner ring) retrieved among the analyzed samples. External colored ring indicates chromosomes. Red bars represent deletions, while green ones show amplifications. The grid behind the bars shows the number of samples presenting rearrangements. The thin lines in the bars represent the presence of only a part of the aberration in some samples. The curved lines in the inner ring indicate the fusion genes in their exact location. Gene names are shown on the outer ring. B Heatmap representing aCGH-derived genomic rearrangements in the 30 samples considered for analysis. Each raw represents a chromosome while each column represents a patient whose numeric code is listed in the lower side. Shades of red and green indicate the rearrangement type as shown in the side legend. The bar with the different color blue shades represents tumor grades. C Boxplot representing gene counts between samples showing (green) or lacking (grey) amplification of chromosome 19. D Boxplot representing gene counts between samples having (red) or not (grey) deletion of chromosome 22