Table 4 Correlation analysis between eIF6 and relate genes and markers of adaptive immunity cells in ESCA
Description | Genemarkers | TIMER (n = 184) | GEPIA2 (n = 181) | ||||
|---|---|---|---|---|---|---|---|
Purity | None | ||||||
Cor | p | Cor | p | Cor | p | ||
CD8 + Tcell | CD8A |  − 0.136 | 0.067 |  − 0.144 | 0.050 |  − 0.130 | 0.086 |
|  | CD8B |  − 0.070 | 0.347 |  − 0.087 | 0.241 |  − 0.110 | 0.140 |
T cell | CD3D |  − 0.108 | 0.147 |  − 0.114 | 0.121 |  − 0.170 | * |
(general) | CD3E |  − 0.143 | 0.055 |  − 0.155 | * |  − 0.200 | * |
|  | CD2 |  − 0.167 | * |  − 0.178 | * |  − 0.190 | * |
Bcell | CD19 |  − 0.009 | 0.906 |  − 0.026 | 0.728 |  − 0.120 | 0.120 |
|  | CD20 (MS4A1) |  − 0.051 | 0.496 |  − 0.070 | 0.345 |  − 0.100 | 0.160 |
|  | CD138 (SDC1) |  − 0.084 | 0.262 |  − 0.054 | 0.466 |  − 0.044 | 0.550 |
|  | CD23 (FCER2) |  − 0.004 | 0.960 |  − 0.019 | 0.792 |  − 0.110 | 0.130 |
Th1 | T-bet (TBX21) |  − 0.162 | * |  − 0.172 | * |  − 0.190 | * |
|  | STAT4 |  − 0.242 | * |  − 0.242 | * |  − 0.200 | * |
|  | STAT1 |  − 0.097 | 0.195 |  − 0.089 | 0.229 | 0.003 | 0.960 |
|  | IFN-γ (IFNG) |  − 0.094 | 0.207 |  − 0.090 | 0.222 |  − 0.150 | * |
|  | TNF-α (TNF) |  − 0.029 | 0.695 |  − 0.008 | 0.913 |  − 0.028 | 0.710 |
Th2 | GATA3 |  − 0.124 | 0.097 |  − 0.117 | 0.113 |  − 0.092 | 0.220 |
|  | STAT6 |  − 0.038 | 0.612 |  − 0.037 | 0.616 | 0.057 | 0.440 |
|  | STAT5A |  − 0.072 | 0.334 |  − 0.081 | 0.276 |  − 0.063 | 0.390 |
|  | IL13 |  − 0.116 | 0.119 |  − 0.112 | 0.130 |  − 0.140 | 0.061 |
Tfh | BCL6 |  − 0.382 | * |  − 0.348 | * |  − 0.270 | * |
|  | IL21 |  − 0.112 | 0.132 |  − 0.106 | 0.152 |  − 0.180 | * |
|  | CD278 (ICOS) |  − 0.225 | * |  − 0.215 | * |  − 0.190 | * |
|  | CXCL13 |  − 0.169 | * |  − 0.174 | * |  − 0.170 | * |
Th17 | STAT3 |  − 0.085 | 0.257 |  − 0.073 | 0.321 |  − 0.042 | 0.570 |
| Â | IL17A | 0.226 | * | 0.205 | * | 0.053 | 0.480 |
Treg | FOXP3 |  − 0.245 | * |  − 0.239 | * |  − 0.210 | * |
|  | CCR8 |  − 0.260 | * |  − 0.266 | * |  − 0.230 | * |
|  | STAT5B |  − 0.166 | * |  − 0.160 | * |  − 0.084 | 0.260 |
|  | TGFβ (TGFB1) |  − 0.122 | 0.103 |  − 0.091 | 0.217 |  − 0.076 | 0.310 |
|  | CD25 (IL2RA) |  − 0.255 | * |  − 0.248 | * |  − 0.180 | * |
T cell exhaustion | PD-1 (PDCD1) |  − 0.116 | 0.121 |  − 0.120 | 0.104 |  − 0.130 | 0.078 |
CTLA4 |  − 0.205 | * |  − 0.205 | * |  − 0.200 | * | |
|  | LAG3 |  − 0.158 | * |  − 0.157 | * |  − 0.085 | 0.250 |
|  | TIM-3 (HAVCR2) |  − 0.250 | * |  − 0.236 | * |  − 0.230 | * |
|  | GZMB |  − 0.108 | 0.149 |  − 0.108 | 0.144 |  − 0.099 | 0.180 |