Fig. 5
From: Homoharringtonine is synergistically lethal with BCL-2 inhibitor APG-2575 in acute myeloid leukemia
HHT reverses the resistance of APG-2575 via inhibiting the PI3K/AKT/GSK3β pathway. A The level of proteins in PI3K/AKT/GSK3β signaling pathway and the MCL-1(Thr163, Thr163/Ser159) were measured after treatment with APG-2575 and HHT for 4 h. And the MCL-1 for 6 h. (in vitro and in vivo). B Schematic of APG-2575 and HHT in AML. HHT inhibits the PI3K/AKT/GSK3β pathway, which interfere with MCL-1 stability, thereby accelerating MCL-1 degradation