Fig. 7

CircMID1 deficiency inhibited MDSC-Exo-induced prostate cancer growth in vivo. A Representative images of xenograft tumors in nude mice (n = 5/group). B The tumor volume was monitored every 5 days for 30 days. ^**P < 0.01. C The tumor weight was determined at the end point of the xenograft experiment. ^**,##P < 0.01, ^* vs. control, ^# vs. Exo. D The relative expressions of circMID1, miR-506-3p, and MID1 were analyzed by qRT-PCR in tumor tissues. E The expression of proliferation marker Ki67 in each group, detected by immunohistochemistry immunofluorescence (scale bar, 50 μM). F The expression of invasion-related factor MMP-2 in each group, detected by immunohistochemistry (scale bar, 50 μM). ^**,## P < 0.01, ^* vs. control, ^# vs. Exo. The measurement data were expressed as the mean ± standard deviation (SD). All experiments were repeated at least three times