From: Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases
Source of exosomes | Intermediate molecule | Downstream pathway or molecule | Models or cells | Effect on downstream pathway | Function | Refs. |
---|---|---|---|---|---|---|
ADSC | miRNA-26b | Kpna2 | Schwann cells | – | Reducing autophagy of injured SCs | [132] |
BMSC | NA | VEGFA | NA | NA | Promoting the regeneration of peripheral nerves | [136] |
ADSC | NA | Bcl-2 mRNA, Bax mRNA | Schwann cells |  + ,– | Reducing the apoptosis of SCs | [138] |
NA | NADPH oxidase 2 complexes | NOX2-PI3K-p-Akt | NA | NA | Regulating axonal regeneration | [140] |