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Table 4 The role of exosomes in gliomas

From: Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Source of exosomes Intermediate molecule Downstream pathway or molecule Models or cells Function Refs.
Hypoxic GSCs miR-30b-3p NA NA Conferring TMZ resistance on glioblastoma [77]
M2 BMDM miR-21 PEG3 NA Promoting immune escape of glioma cells [78]
Hypoxia-induced glioma cells miR-29a, miR-92a NA NA Promoting immune escape [80]
Stem-like BTICs TNC T cell NA Suppressing the immune system [81]
NA miR-301a Wnt / β-catenin NA Reducing radiosensitivity [85]
MSC miR-146 NA Rat primary brain tumor model Inhibiting the growth of glioma xenografts [88]
WJ-MSCs miR-124 NA GBM Enhancing the sensitivity to TMZ and reduce the migration [89]
  1. 'NA' means no accessible data in the study.
  2. GSCs, Glioma stem-like cells; TMZ, temozolomide; BMDM, bone marrow-derived macrophage; BTICs, brain tumor initiating cells; TNC, tenascin-C; MSC, mesenchymal stem cells; WJ-MSCs, Wharton's Jelly- Derived Mesenchymal Stem Cells; GBM, glioblastoma multiforme