Table 4 The role of exosomes in gliomas
From: Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases
Source of exosomes | Intermediate molecule | Downstream pathway or molecule | Models or cells | Function | Refs. |
|---|---|---|---|---|---|
Hypoxic GSCs | miR-30b-3p | NA | NA | Conferring TMZ resistance on glioblastoma | [77] |
M2 BMDM | miR-21 | PEG3 | NA | Promoting immune escape of glioma cells | [78] |
Hypoxia-induced glioma cells | miR-29a, miR-92a | NA | NA | Promoting immune escape | [80] |
Stem-like BTICs | TNC | T cell | NA | Suppressing the immune system | [81] |
NA | miR-301a | Wnt / β-catenin | NA | Reducing radiosensitivity | [85] |
MSC | miR-146 | NA | Rat primary brain tumor model | Inhibiting the growth of glioma xenografts | [88] |
WJ-MSCs | miR-124 | NA | GBM | Enhancing the sensitivity to TMZ and reduce the migration | [89] |