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Table 3 The role of exosomes in stroke

From: Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Source of exosomes Intermediate molecule Downstream pathway or molecule Models or cells Effect on downstream pathway Function Refs.
MSC NA IL-1β Mice with ischemic stroke Improving angiogenesis and neurogenesis [67]
IL-4-polarized BV2 microglia cells miRNA-26a NA NA NA Promoting angiogenesis [68]
Endothelial cell miR-126 NA T2DM mice with stroke NA Promoting neurorestoration [70]
  1. 'NA' means no accessible data in the study.
  2. MSC, mesenchymal stem cells; T2DM, type 2 diabetes mellitus
  3. '–' represents the inhibition of downstream pathway or molecule