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Table 3 The role of exosomes in stroke

From: Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Source of exosomes

Intermediate molecule

Downstream pathway or molecule

Models or cells

Effect on downstream pathway

Function

Refs.

MSC

NA

IL-1β

Mice with ischemic stroke

–

Improving angiogenesis and neurogenesis

[67]

IL-4-polarized BV2 microglia cells

miRNA-26a

NA

NA

NA

Promoting angiogenesis

[68]

Endothelial cell

miR-126

NA

T2DM mice with stroke

NA

Promoting neurorestoration

[70]

  1. 'NA' means no accessible data in the study.
  2. MSC, mesenchymal stem cells; T2DM, type 2 diabetes mellitus
  3. '–' represents the inhibition of downstream pathway or molecule