From: Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases
Source of exosomes | Intermediate molecule | Downstream pathway or molecule | Models or cells | Effect on downstream pathway | Function | Refs. |
---|---|---|---|---|---|---|
MSC | NA | IL-1β | Mice with ischemic stroke | – | Improving angiogenesis and neurogenesis | [67] |
IL-4-polarized BV2 microglia cells | miRNA-26a | NA | NA | NA | Promoting angiogenesis | [68] |
Endothelial cell | miR-126 | NA | T2DM mice with stroke | NA | Promoting neurorestoration | [70] |