Subgroup | Parameters | Univariate analysis | Multivariate analysis | |||||||
---|---|---|---|---|---|---|---|---|---|---|
HR | HR.95L | HR.95H | P value | Coef. | HR | HR.95L | HR.95H | P value | ||
All patient (n = 14,946) | Age | 1.033 | 1.031 | 1.035 | < 0.001 | 0.015 | 1.016 | 1.013 | 1.018 | < 0.001 |
PT | 2.671 | 2.588 | 2.756 | < 0.001 | 0.299 | 1.348 | 1.286 | 1.414 | < 0.001 | |
PN | 3.826 | 3.584 | 4.084 | < 0.001 | 0.044 | 1.044 | 0.964 | 1.131 | 0.285 | |
PM | 7.288 | 6.798 | 7.814 | < 0.001 | 0.245 | 1.278 | 1.155 | 1.414 | < 0.001 | |
Stage | 2.809 | 2.718 | 2.902 | < 0.001 | 0.787 | 2.197 | 2.054 | 2.351 | < 0.001 | |
Radiation/surgery | 0.784 | 0.724 | 0.848 | < 0.001 | − 0.263 | 0.769 | 0.708 | 0.836 | < 0.001 | |
Chemotherapy | 2.985 | 2.772 | 3.215 | < 0.001 | − 0.208 | 0.812 | 0.746 | 0.885 | < 0.001 | |
Stage 1 (n = 7404) | Age | 1.040 | 1.033 | 1.047 | < 0.001 | 0.032 | 1.033 | 1.026 | 1.040 | < 0.001 |
PT | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
PN | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
PM | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
Radiation/surgery | 2.259 | 1.842 | 2.770 | < 0.001 | − 0.046 | 0.955 | 0.757 | 1.206 | 0.699 | |
Chemotherapy | 4.538 | 3.738 | 5.510 | < 0.001 | 1.369 | 3.931 | 3.141 | 4.921 | < 0.001 | |
Stage 2 (n = 2071) | Age | 1.018 | 1.011 | 1.024 | < 0.001 | 0.015 | 1.015 | 1.008 | 1.022 | < 0.001 |
PT | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
PN | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
PM | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
Radiation/surgery | 0.699 | 0.568 | 0.861 | < 0.001 | − 0.281 | 0.755 | 0.612 | 0.932 | 0.009 | |
Chemotherapy | 0.574 | 0.465 | 0.707 | < 0.001 | − 0.494 | 0.610 | 0.494 | 0.753 | < 0.001 | |
Stage 3 (n = 3485) | Age | 1.016 | 1.012 | 1.020 | < 0.001 | 0.006 | 1.006 | 1.002 | 1.010 | 0.003 |
PT | 1.736 | 1.617 | 1.864 | < 0.001 | 0.514 | 1.672 | 1.529 | 1.827 | < 0.001 | |
PN | 0.616 | 0.549 | 0.690 | < 0.001 | 0.180 | 1.197 | 1.047 | 1.369 | 0.009 | |
PM | NR | NR | NR | NR | NR | NR | NR | NR | NR | |
Radiation/surgery | 0.495 | 0.438 | 0.560 | < 0.001 | − 0.315 | 0.730 | 0.639 | 0.834 | < 0.001 | |
Chemotherapy | 0.610 | 0.531 | 0.700 | < 0.001 | − 0.446 | 0.640 | 0.556 | 0.737 | < 0.001 | |
Stage 4 (n = 1986) | Age | 1.014 | 1.010 | 1.018 |  < 0.001 | 0.005 | 1.005 | 1.001 | 1.009 |  < 0.001 |
PT | 1.172 | 1.114 | 1.233 | < 0.001 | 0.234 | 1.264 | 1.189 | 1.343 | < 0.001 | |
PN | 1.028 | 0.919 | 1.149 | 0.633 | 0.009 | 1.009 | 0.899 | 1.132 | 0.882 | |
PM | 1.219 | 1.045 | 1.422 | 0.012 | 0.610 | 1.841 | 1.539 | 2.202 | < 0.001 | |
Radiation/surgery | 0.437 | 0.374 | 0.511 | < 0.001 | − 0.621 | 0.537 | 0.458 | 0.631 | < 0.001 | |
Chemotherapy | 0.388 | 0.345 | 0.436 | < 0.001 | − 0.867 | 0.420 | 0.372 | 0.474 | < 0.001 |