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Table 1 Analysis of the survival of C57BL/6 mice after treatment with GANT, AFA, and AFA + GANT by the log-rank test (Mantel-Cox)

From:  Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo

   

Hazard Ratio(HR)

95% HR Confidence intervals

Median Survival

(day)

p-value

CTR

vs

GANT

3.761

(1.016, 13.91)

30 vs 34.5

0.05

CTR

vs

AFA

12.58

(2.908, 54.45)

30 vs 38

0.002

CTR

vs

AFA + GANT

21.00

(4.548, 96.91)

30 vs 49

0.0003

GANT

vs

AFA

3.092

(0.9098, 10.51)

34.5 vs 38

0.04

GANT

vs

AFA + GANT

9.369

(2.335, 37.58)

34.5 vs 49

0.002

AFA

vs

AFA + GANT

3.746

(1.106, 12.69)

38 vs 49

0.05

  1. CTR: control (PBS + DMSO); GANT: GANT-61; AFA: Afatinib; AFA + GANT: Afatinib + GANT-61