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Fig. 4 | Journal of Translational Medicine

Fig. 4

From:  Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo

Fig. 4

Effects of GANT and AFA, alone or in combination, on cell cycle distribution. Stacked bar graphs show the percentage of cells in subG1, G0/G1, S, and G2/M phases, as calculated with CellQuest Pro 5.2 software. Results represent mean values from two independent experiments. Statistical significance of the effects obtained with GANT and AFA, alone or in combination, was calculated vs those obtained in (1) DMSO-, (2) GANT- and (3) AFA-treated cells with one-way ANOVA. The statistical significance of the effect obtained with GANT 20, AFA 10, or AFA 10 + GANT 20 in the presence of the Z-VAD-FMK inhibitor (Z-VAD) was calculated with respect to that obtained in cells treated with GANT 20, AFA 10, or AFA 10 + GANT 20, respectively. ×p < 0.05; *p < 0.01; #p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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