Skip to main content

Table 1 Summary of in vivo results showing the Exos-based periodontitis treatment strategy used over the past 5 years

From: Advances of exosomes in periodontitis treatment

Source of Exos

Study model

Route of delivery

Dose

Duration

Outcomes

References

MSCs

Mouse experimental periodontitis model

Locally injection

50 μg per mouse

14 days

Improve the treatment by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis

[46]

DPSCs

Mouse experimental periodontitis model

Incorporated chitosan hydrogel

50 μg

4 weeks

Facilitate macrophages from M1 to M2 phenotype and promote alveolar bone healing

[47]

HHH-DPSCs

Mouse experimental periodontitis model

Directly applied onto the silk ligature

5 μL containing 7.5 × 108 particles

7 days

Promote the migration of both DPCs and osteoblastic cells; suppress osteoclast formation

[48]

PDLSCs

Rat periodontal bone defect model

Mixed with Matrigel

Exos (225 μg/μL): Matrigel = 2:1 (v/v)

4 weeks

Suppress overactivation Wnt signaling, recover osteogenic differentiation capacity of inflammatory PDLSCs

[49]

TNF-α-treated human GMSCs

Mouse experimental periodontitis model

Locally injection

20 μg per mouse

7 days

Regulate inflammation and osteoclastogenesis

[50]

SHED

Mouse experimental periodontitis model

Locally injection

20 μg

2 weeks

Restore bone loss, promote BMSCs osteogenesis, differentiation, and bone formation

[51]

SHED

Rat periodontal defect models

h β-TCP scaffffolds loaded with Exos

2 μg/μL Exos in 100 μL PBS

4 weeks

Contribute to periodontal bone regeneration through the AMPK signaling pathway

[52]

induced M2-like macrophages

Mouse experimental periodontitis model

Locally injection

30 μL (500 ng/ml)

2 weeks

Reduce alveolar bone resorption in mice with periodontitis via IL-10/IL-10R pathway

[53]

ADSCs

Rat experimental periodontitis model

Locally injection

80–150 µg in 200 µL PBS

4 weeks

Represent a promising adjunctive treatment to SRP

[54]

salivary Exos

Insulin resistance-associated mouse experimental periodontitis model

Locally injection

miR-25-3p inhibitors (100 μl of 8 nM)

9 days

Exosomal miR-25-3p in saliva contribute to development and progression of diabetes-associated periodontitis

[55]