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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Secretion of miRNA-326-3p by senescent adipose exacerbates myocardial metabolism in diabetic mice

Fig. 6

Senolytic treatment alleviates cardiac function in STZ mice. A Experiment design for senolytic treatment in vivo. B Representative images and C quantification of (SA-β-gal) staining of EAT isolated from Veh or Seno treated STZ-mice (n = 3 per group). D Relative gene expression of senescence associated genes in Veh or Seno treated STZ-EAT (n = 3 per group). E Representative of doppler and tissue doppler echocardiography and evaluation of diastolic function (n = 6 per group). F Contractile function and G calcium handling of AMVMs isolated from Veh or Seno treated STZ-mice were evaluated (n = 5 per group). H Representative transmission electron micrographs of Veh or Seno treated STZ-mice hearts. Relative miRNA-326-3p expression in I blood and J AMVMs from Veh or Seno treated STZ-mice (n = 4–5 per group). K Protein levels of Rictor, p-AKT, AKT and Gapdh in AMVMs isolated from Veh or Seno treated STZ-mice evaluated by immunoblotting (n = 3). Data are presented as the mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared to Veh group

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