Fig. 6

FGF23 overexpression attenuated the rhein-mediated inhibitory effect on cardiac remodeling in mice. A The heart mass/body mass, heart mass/TL, and LW/BW ratios (n = 6 per group). B Cardiac function was assessed by the EF% (scale bar = 200 μm; n = 6 per group). C Representative images of H&E-stained LV transverse sections (scale bar, 50 μm; n = 6 per group). D Representative micrographs and quantification of the DHE-stained superoxide anion levels (n = 5 per group). E ANP, BNP, collagen I, collagen III, NOX2, and NOX4 mRNA levels in mouse hearts (n = 5 per group). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. the Ang II + LV-GFP group; ^#P < 0.05, ^##P < 0.01, and ^***P < 0.001 vs. the Ang II + rhein100 + LV-GFP group