Fig. 1

Rhein suppressed Ang II-induced cardiac remodeling in mice. A The heart mass/body mass, heart mass/TL, and LW/BW ratios (n = 7 per group). B Cardiac function was assessed by the EF% (scale bar = 200 μm; n = 7 per group). C Representative images of H&E-stained LV transverse sections (scale bar = 50 μm; n = 6 per group). D PSR-stained LV cross-sections (scale bar = 50 μm; n = 5 per group). E Representative micrographs and quantification of DHE-stained superoxide anion levels (n = 5 per group). F ANP, BNP, β-MHC, TGF-β₁, collagen I, and collagen III mRNA levels in mouse hearts (n = 5 per group). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. the sham group; ^#P < 0.05 and ^##P < 0.01 vs. the Ang II group