Skip to main content
Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer

Fig. 5

TIGIT/CD155 signalling suppresses the activation of the NF-κB and ERK pathways. A Activated CD8+ T cells were stimulated with αCD3/CD28 and cocultured with tumour cells in the presence of an anti-TIGIT blocking antibody, anti-PD-1 blocking antibody. Activated CD8+ T cells were treated with CD155-Fc. Expression levels of p-ERK/ERK, p-IκBα and p-NF-κBP65. B SHIP-1 was associated with negative regulation of T cell activation. We performed Co-IP analysis and observed that TIGIT could precipitate SHIP-1 under the action of Fc-CD155. The data are the mean ± SEM of at least three independent experiments. *P < 0.05, **P < 0.01

Back to article page