Skip to main content

Table 2 Metabolic changes in serum samples from BPH, PCa, and PCaB

From: Identification of characteristic metabolic panels for different stages of prostate cancer by 1H NMR-based metabolomics analysis

Metabolites

(r.u.)

BPHc

PCad

PCaBe

PCa vs BPH

PCaB vs BPH

PCaB vs PCa

p valuea

FDRb

p value

FDR

p value

FDR

3-HBf

9.31 ± 5.69

6.18 ± 3.51

8.86 ± 7.11

0.000

0.002

0.701

0.818

0.013

0.022

Acetate

2.11 ± 0.61

1.99 ± 0.63

1.92 ± 0.99

0.250

0.397

0.219

0.348

0.682

0.853

Acetoacetate

2.36 ± 1.19

2.14 ± 0.89

1.94 ± 0.92

0.210

0.397

0.025

0.036

0.245

0.452

Acetone

5.77 ± 4.36

3.21 ± 2.24

5.21 ± 5.21

0.000

0.001

0.528

0.684

0.010

0.042

Alanine

16.80 ± 2.71

18.57 ± 2.52

17.37 ± 3.45

0.000

0.002

0.307

0.413

0.028

0.047

Creatine

2.62 ± 0.62

2.63 ± 0.55

2.36 ± 0.70

0.122

0.330

0.013

0.046

0.026

0.031

Creatinine

1.03 ± 0.32

1.02 ± 0.29

1.00 ± 0.35

0.970

0.970

0.608

0.761

0.632

0.819

Citrate

2.44 ± 0.56

2.34 ± 0.43

2.56 ± 0.61

0.232

0.397

0.137

0.266

0.020

0.031

Formate

0.09 ± 0.04

0.11 ± 0.04

0.12 ± 0.04

0.124

0.330

0.009

0.045

0.204

0.398

Glutamine

18.97 ± 3.20

17.84 ± 2.68

17.70 ± 4.18

0.026

0.047

0.012

0.047

0.829

0.893

Glycine

8.29 ± 1.87

8.01 ± 1.54

8.41 ± 2.48

0.346

0.526

0.771

0.856

0.315

0.550

Gycerol

9.60 ± 1.77

9.50 ± 2.58

10.18 ± 2.75

0.057

0.810

0.178

0.226

0.142

0.193

Histidine

1.20 ± 0.21

1.13 ± 0.18

1.09 ± 0.21

0.022

0.037

0.001

0.035

0.962

0.985

Isoleucine

2.73 ± 0.47

2.72 ± 0.39

2.55 ± 0.43

0.921

0.970

0.012

0.043

0.028

0.035

Lactate

100.63 ± 36.14

92.09 ± 29.81

90.63 ± 33.26

0.040

0.157

0.215

0.348

0.561

0.818

LDL/VLDL

56.61 ± 21.04

61.83 ± 20.69

52.34 ± 23.60

0.147

0.344

0.289

0.404

0.023

0.031

Leucine

13.53 ± 2.02

13.31 ± 1.64

12.63 ± 2.03

0.468

0.655

0.003

0.035

0.005

0.038

Lysine

2.46 ± 0.33

2.54 ± 0.46

2.37 ± 0.45

0.249

0.397

0.235

0.357

0.051

0.137

Phenylalanine

0.68 ± 0.26

0.72 ± 0.31

0.84 ± 0.35

0.078

0.249

0.002

0.028

0.026

0.049

Pyruvate

1.65 ± 0.44

1.65 ± 0.38

1.93 ± 0.56

0.969

0.970

0.002

0.028

0.002

0.034

Threonine

1.76 ± 0.31

1.73 ± 0.40

1.70 ± 0.33

0.623

0.838

0.254

0.370

0.613

0.819

Tyrosine

0.94 ± 0.19

1.02 ± 0.15

1.01 ± 0.33

0.029

0.041

0.180

0.315

0.833

0.893

Valine

9.37 ± 1.47

9.35 ± 1.32

8.65 ± 1.57

0.872

0.970

0.003

0.036

0.034

0.039

α-Glucose

14.19 ± 3.07

14.89 ± 2.89

15.31 ± 3.46

0.177

0.386

0.049

0.167

0.475

0.722

β-Glucose

12.81 ± 3.10

12.98 ± 3.29

12.97 ± 3.45

0.752

0.970

0.782

0.856

0.985

0.985

  1. Data were presented as Mean ± SD
  2. aAdjusted by Bonferroni correction across multiple comparisons within each metabolite
  3. bAdjusted by false discovery rate (FDR) method across the metabolites within each comparison
  4. cBPH, patient with benign prostatic hyperplasia
  5. dPCa, prostate cancer
  6. ePCaB, prostate cancer with bone metastasis
  7. f3-HB, 3-hydroxybutyrate. The colored p value represents significantly decreased (green) or increased (red) from BPH to PCa, BPH to PCaB or PCa to PCaB