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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Comprehensive analysis of microglia gene and subpathway signatures for glioma prognosis and drug screening: linking microglia to glioma

Fig. 1

Microglia specific biological characterization and interaction network. A Two level of comparison analysis, microglia tumor vs macrophage tumor (MicT/MacT) as well as microglia tumor vs microglia normal (MicT/MicN), were performed. Bra indicated the brain tissue, epi indicated the epilepsy tissue, and pos indicated the postmortem tissue. The enrichment analysis for biological functions were performed based on signatures which existed at least two data sets (overlapping signatures). For MicT/MacT comparison, the functional analysis for the signatures which existed at least three data sets were further performed. B The associations between overlapping signatures (shared by three data sets) and known functional hall-markers derived from gene sets in The Molecular Signatures Database (MsigDB). The significant value was calculated by hypergeometric test. C The interaction network for gene signatures involved in MicT/MacT and MicT/MicN groups. The hub or key genes were shown in the network

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