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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Treatment with eFT-508 increases chemosensitivity in breast cancer cells by modulating the tumor microenvironment

Fig. 7

Treatment with eFT-508 restores the functional activity of tumor-infiltrating CD8 + T cells. A Expression of cytokines in tumor-infiltrating CD8 + T cells isolated from mice treated with vehicle control or eFT-508 ± PMA/Ionomycin. Data are mean ± SD. B Effector function was evaluated by a mixed lymphocyte reaction (MLR) assay. CD8 + T cells isolated from vehicle-treated mice were dysfunctional in comparison to cells isolated from eFT-508 treated mice (n = 5). *P < 0.05, ****P < 0.0001, ns—not significant (P > 0.05)

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