Fig. 7

Proteomics sequencing results and analysis. A Volcano map of differential proteins, threshold of fold change (FC) was set as |log2FC|> 0.5, P < 0.05. B Heat map of differential proteins. C Heat map of the top 20 differential proteins, red arrow indicates that LAGE1 is one of these proteins. D The expression level of RAF1-correlated proteins was analyzed by NetworkAnalyst. Red arrow indicates that LAGE1 had the most significant expression difference between groups. E GO terms analysis; F KEGG pathway enrichment analysis. Abbreviations: sh-RNA, short hairpin RNA; NC, negative control. *P < 0.05, **P < 0.01, ***P < 0.001