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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis

Fig. 5

TRIM2 is regulated by EPI and participates in the regulation of EMT and CSCs in CRC. A A cluster heatmap of the expression profiles of mRNAs in DMSO- and Epi-treated HCT116 cells. B Ubiquitin-related genes among the differentially expressed genes. C Immunoblot analysis indicated that TRIM2 expression is regulated by EPI. D Western blot analysis revealed that TRIM2 promotes EMT and CSCs in CRC cells. E–G Mammosphere culture analysis revealed that TRIM2 promotes CSCs in CRC cells. H-I Transwell assays revealed that TRIM2 promotes migration in CRC cells. J-K Colony formation assays revealed that TRIM2 promotes proliferation in CRC cells. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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