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Table 3 Power estimate for 102 subjects based on peak VO2

From: Rationale and design of interleukin-1 blockade in recently decompensated heart failure (REDHART2): a randomized, double blind, placebo controlled, single center, phase 2 study

 

Peak VO2

Effect size of treatment on top of placebo

mL•kg−1• min−1

 + 1.2

 + 1.4

 + 1.6

 + 2.4

 + 3.2

Standard deviation

2.3

0.70

0.83

0.91

 > 0.99

 > 0.99

2.0

0.82

0.92

0.97

 > 0.99

 > 0.99

1.7

0.92

0.98

0.99

 > 0.99

 > 0.99

1.4

0.98

0.99

 > 0.99

 > 0.99

 > 0.99

  1. Power estimation based on treatment effect of anakinra on the peak VO2 on the top of placebo for 102 subjects