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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Diagnostic potential of a circulating miRNA model associated with therapeutic effect in heart failure

Fig. 2

Identification of the medical therapy-associated circulating miRNAs in heart failure (HF) patients. A QRT-PCR based screening of circulating miRNAs in the plasma samples of HF patients (n = 40) before and after medical treatment. Comparisons were made by before treatment vs after treatment. Six miRNAs were identified to be significantly associated with the therapeutic effect, including miR-654-5p with upregulation and miR-30a-5p, 449b, 320a, 433 and 100 with downregulation after treatment. By applying cutoffs with fold change (FC) > 1.5 and p < 0.05, miR-30a-5p and miR-654-5p were screened out as the most significantly changed miRNAs. B, C Expression patterns of miR-30a-5p (B) and miR-654-5p (C) in each inpatient in the discovery cohort with paired plasma samples collected at times of check-in and check-out. Two-tailed p-values were calculated using paired samples t-tests

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