Table 1 Genetic background of breast cancer cell lines and antiproliferative effect of drugs alone
CELL LINE | ER amplification | HER2 amplification | Mutations | Additional features | IPATASERTIB IC50 | TASELISIB IC50 |
|---|---|---|---|---|---|---|
MDAMB231 | − | − | KRAS/B-RAF | p53 NF2 p16 CDKN2 p14 CDKN2A | 70 µM | 25 µM |
MDAMB468 | − | − | PTEN null | EGFR ampification p53 SMAD4 RB1 | 5 µM | 2.5 µM |
MCF7 | + | − | PI3KCA | p16 CDKN2 p14 CDKN2A | 10 µM | 500 nM |
SKBR3 | − | + | wt | p53 | 500 nM | 50 nM |
MDAMB361 | + | + | PI3KCA | NA | 1 µM | 100 nM |