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Table 1 Genetic background of breast cancer cell lines and antiproliferative effect of drugs alone

From: Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

CELL LINE ER amplification HER2 amplification Mutations Additional features IPATASERTIB IC50 TASELISIB IC50
MDAMB231 KRAS/B-RAF p53
NF2
p16 CDKN2
p14 CDKN2A
70 µM 25 µM
MDAMB468 PTEN null EGFR ampification
p53
SMAD4
RB1
5 µM 2.5 µM
MCF7  +  PI3KCA p16 CDKN2
p14 CDKN2A
10 µM 500 nM
SKBR3  +  wt p53 500 nM 50 nM
MDAMB361  +   +  PI3KCA NA 1 µM 100 nM