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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

Fig. 2

Ipatasertib and taselisib treatment induces Autophagy in all breast cancer analyzed. a The exposure to fixed dose (IC50) of ipatasertib and taselisib induces the reduction of expression of phospho-mTOR, associated with the increase of autophagy signaling, as showed by increase of LC3 II/LC3 I ratio by immunoblot assay by reduction of p62 and p-ULK1-ser758, or increase of ATG5 after 24 h of exposure in MCF7, SKBR3, MDAMB231 and MDAMB468 cell lines. In MDAMB231 cell line the maximum dosage of 10 µM was used for both drugs. Statistically significant results are reported (*** indicates P < 0.0005, ** indicates P < 0.005 and * indicates P < 0.05)

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Journal of Translational Medicine

ISSN: 1479-5876

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