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Table 4 The odd ratios of treatments for patients with and without chronic fatigue syndrome in difference subgroup of age

From: Treatments of chronic fatigue syndrome and its debilitating comorbidities: a 12-year population-based study

Variable Control
(n = 6306)
CFS
(n = 6306)
Odds ratio
Age ≤ 34 y/o Crude (95% CI) p-value Adjusted (95% CI) p-value
No Yes No Yes
SSRI      1.98 (1.43,2.74)*** < 0.001 1.53 (1.08,2.15)* 0.015
 No 4758 1188 4386 1139     
 Yes 300 60 667 114     
SNRI      2.13 (1.23,3.7)** 0.007 1.39 (0.77,2.52) 0.272
 No 4966 1229 4852 1213     
 Yes 92 19 201 40     
SARI      1.82 (1.25,2.65)** 0.002 1.20 (0.8,1.8) 0.375
 No 4724 1203 4351 1173     
 Yes 334 45 702 80     
TCAs      2.17 (1.12,4.21)* 0.022 1.59 (0.78,3.22) 0.2
 No 4962 1235 4888 1225     
 Yes 96 13 165 28     
BZD      1.91 (1.62,2.25)*** < 0.001 1.61 (1.36,1.92)*** < 0.001
 No 2380 880 1411 697     
 Yes 2678 368 3642 556     
NDRI      2.29 (0.94,5.59) 0.068 1.34 (0.5,3.56) 0.557
 No 5025 1241 4973 1237     
 Yes 33 7 80 16     
Muscle relaxant      1.88 (1.1,3.21)* 0.021 1.69 (0.97,2.96) 0.065
 No 4912 1227 4797 1214     
 Yes 146 21 256 39     
Analgesic drug      3.94 (2.57,6.02)*** < 0.001 3.89 (2.49,6.06)*** < 0.001
 No 968 103 74 28     
 Yes 4090 1145 4979 1225     
Supportive individual psychotherapy      1.74 (1.23,2.45)** 0.002 1.13 (0.77,1.64) 0.531
 No 4839 1193 4645 1160     
 Yes 219 55 408 93     
Intensive individual psychotherapy      5.37 (1.56,18.47)** 0.008 3.34 (0.92,12.17) 0.067
 No 5047 1245 5014 1237     
 Yes 11 3 39 16     
Re-educative individual psychotherapy      1.85 (1.29,2.65)*** < 0.001 1.20 (0.81,1.79) 0.362
 No 4858 1199 4659 1165     
 Yes 200 49 394 88     
Stretching exercise      1.21 (0.86,1.70) 0.274 1.15 (0.81,1.63) 0.425
 No 4701 1183 4541 1175     
 Yes 357 65 512 78     
Therapeutic exercise      1.08 (0.84,1.39) 0.544 0.98 (0.76,1.28) 0.89
 No 4418 1117 4121 1112     
 Yes 640 131 932 141     
Brainwave examination, sleep or wakefulness     0.63 (0.24,1.64) 0.344 0.60 (0.22,1.65) 0.321
 No 4937 1237 4923 1246     
 Yes 121 11 130 7     
Variable Control
(n = 6306)
CFS
(n = 6306)
Odds ratio
Age 35–64 y/o Crude (95% CI) p-value Adjusted (95% CI) p-value
No Yes No Yes
SSRI      2.15 (1.85,2.50)*** < 0.001 1.57 (1.34,1.85)*** < 0.001
 No 1389 4557 1251 4274     
 Yes 82 278 220 561     
SNRI      2.23 (1.71,2.90)*** < 0.001 1.56 (1.18,2.07)** 0.002
 No 1443 4752 1411 4654     
 Yes 28 83 60 181     
SARI      2.19 (1.88,2.55)*** < 0.001 1.53 (1.3,1.81)*** < 0.001
 No 1356 4571 1232 4292     
 Yes 115 264 239 543     
TCAs      2.09 (1.57,2.79)*** < 0.001 1.66 (1.22,2.24)** 0.001
 No 1432 4765 1422 4691     
 Yes 39 70 49 144     
BZD      2.15 (1.98,2.33)*** < 0.001 1.71 (1.56,1.87)*** < 0.001
 No 474 2786 236 1872     
 Yes 997 2049 1235 2963     
NDRI      2.19 (1.46,3.3)*** < 0.001 1.52 (0.99,2.35) 0.057
 No 1465 4801 1449 4761     
 Yes 6 34 22 74     
Muscle relaxant      1.73 (1.38,2.18)*** < 0.001 1.46 (1.14,1.85)** 0.002
 No 1424 4715 1380 4631     
 Yes 47 120 91 204     
Analgesic drug      9.18 (7.27,11.59)*** < 0.001 6.83 (5.38,8.66)*** < 0.001
 No 410 661 20 82     
 Yes 1061 4174 1451 4753     
Supportive individual psychotherapy      1.82 (1.53,2.16)*** < 0.001 1.20 (1,1.45) 0.054
 No 1415 4617 1352 4453     
 Yes 56 218 119 382     
Intensive individual psychotherapy      4.11 (2.19,7.75)*** < 0.001 2.95 (1.52,5.73)** 0.001
 No 1469 4823 1465 4786     
 Yes 2 12 6 49     
Re-educative individual psychotherapy      2.01 (1.68,2.39)*** < 0.001 1.33 (1.1,1.61)** 0.004
 No 1423 4634 1376 4448     
 Yes 48 201 95 387     
Stretching exercise      1.43 (1.23,1.67)*** < 0.001 1.27 (1.08,1.49)** 0.004
 No 1360 4524 1315 4401     
 Yes 111 311 156 434     
Therapeutic exercise      1.42 (1.26,1.59)*** < 0.001 1.28 (1.13,1.45)*** < 0.001
 No 1256 4279 1150 4083     
 Yes 215 556 321 752     
Brainwave examination, sleep or wakefulness     1.08 (0.79,1.50) 0.622 0.98 (0.69,1.37) 0.889
 No 1411 4763 1412 4757     
 Yes 60 72 59 78     
Variable Control
(n = 6306)
CFS
(n = 6306)
Odds ratio
Age ≥ 65 y/o Crude (95% CI) p-value Adjusted (95% CI) p-value
No Yes No Yes
SSRI      2.98 (2.29,3.88)*** < 0.001 2.17 (1.64,2.88)*** < 0.001
 No 4557 1389 4274 1251     
 Yes 278 82 561 220     
SNRI      2.19 (1.39,3.45)*** < 0.001 1.46 (0.9,2.37) 0.121
 No 4752 1443 4654 1411     
 Yes 83 28 181 60     
SARI      2.29 (1.81,2.89)*** < 0.001 1.69 (1.31,2.17)*** < 0.001
 No 4571 1356 4292 1232     
 Yes 264 115 543 239     
TCAs      1.27 (0.83,1.94) 0.28 0.89 (0.56,1.42) 0.633
 No 4765 1432 4691 1422     
 Yes 70 39 144 49     
BZD      2.49 (2.08,2.97)*** < 0.001 1.72 (1.42,2.09)*** < 0.001
 No 2786 474 1872 236     
 Yes 2049 997 2963 1235     
NDRI      3.71 (1.5,9.17)** 0.005 2.33 (0.9,6.03) 0.082
 No 4801 1465 4761 1449     
 Yes 34 6 74 22     
Muscle relaxant      2.00 (1.39,2.86)*** < 0.001 1.75 (1.2,2.56)** 0.004
 No 4715 1424 4631 1380     
 Yes 120 47 204 91     
Analgesic drug      28.0 (17.77,44.22)*** < 0.001 27.1 (16.65,44.03)*** < 0.001
 No 661 410 82 20     
 Yes 4174 1061 4753 1451     
Supportive individual psychotherapy      2.22 (1.6,3.08)*** < 0.001 1.58 (1.11,2.24)* 0.01
 No 4617 1415 4453 1352     
 Yes 218 56 382 119     
Intensive individual psychotherapy      3.01 (0.61,14.93) 0.178 1.47 (0.26,8.18) 0.662
 No 4823 1469 4786 1465     
 Yes 12 2 49 6     
Re-educative individual psychotherapy      2.05 (1.44,2.92)*** < 0.001 1.28 (0.87,1.88) 0.207
 No 4634 1423 4448 1376     
 Yes 201 48 387 95     
Stretching exercise      1.45 (1.13,1.88)** 0.004 1.29 (0.99,1.69) 0.063
 No 4524 1360 4401 1315     
 Yes 311 111 434 156     
Therapeutic exercise      1.63 (1.35,1.97)*** < 0.001 1.48 (1.21,1.82)*** < 0.001
 No 4279 1256 4083 1150     
 Yes 556 215 752 321     
Brainwave examination, sleep or wakefulness     0.98 (0.68,1.42) 0.925 0.86 (0.58,1.27) 0.447
 No 4763 1411 4757 1412     
 Yes 72 60 78 59     
  1. CFS: chronic fatigue syndrome; CI: confidence interval; *:p-value; *P < .05, **P < .01, ***P < .001