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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Tumor-suppressive MEG3 induces microRNA-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/MYC axis

Fig. 6

MEG3 upregulates miR-493-5p and downregulates the METTL3/MYC axis to promote the sensitivity of Molm13 cells to AraC. Molm13 cells were treated with AraC (2 μM) + sh-MEG3 + sh-MYC, and Molm13 R cells were treated with AraC (2 μM) + oe-MEG3 + oe-MYC. A, MYC expression in Molm13 and Molm13 R cells determined using RT-qPCR. B, The viability of Molm13 and Molm13 R cells evaluated by CCK-8 assay. C, Apoptosis of Molm13 nd Molm13 R cells detected by flow cytometry. D, Expression of Bcl-2, Bax, and cleaved caspase-3 proteins in Molm13 and Molm13 R cells determined using Western blot analysis. * p < 0.05. Cell experiments were performed three times independently

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