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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Tumor-suppressive MEG3 induces microRNA-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/MYC axis

Fig. 3

METTL3 is a target gene of miR-493-5p. A, GO functional enrichment analysis of the candidate genes. B, Differential expression of METTL3 in AML samples in TCGA and GTEx. The red box plot represents disease samples, and the gray box plot represents normal samples. C, starBase was used to predict the binding site of miR-493-5p to METTL3. D, Dual luciferase reporter assay was used to detect the binding of miR-493-5p to METTL3. E, METTL3 expression in bone marrow samples of AML patients (n = 35) and healthy individuals (n = 35) determined by RT-qPCR. F, Correlation analysis between miR-493-5p expression and METTL3 expression in the bone marrow samples of AML patients (n = 35). G, METTL3 expression in HS-5, HL-60 and Molm13 cells and HL-60 R and Molm13 R cells measured by RT-qPCR. H, METTL3 expression in HL-60 and Molm13 cells and HL-60 R and Molm13 R cells upon miR-493-5p inhibitor/mimic determined by RT-qPCR. * p < 0.05. Cell experiments were performed three times independently

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