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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Role of chemokine-mediated angiogenesis in resistance towards crizotinib and its reversal by anlotinib in EML4-ALK positive NSCLC

Fig. 5

The inhibition effect of anlotinib on ALK-positive cell lines. A Dose response curve and half maximal inhibitory concentration (IC50) of anlotinib in H2228, H3122, and H3122CR; B Effect of anlotinib treatment on cell colony formation in H2228, H3122, and H3122CR; C Anlotinib inhibited the mRNA and protein expression of CCL20, CCL24, CCL2, and CX3CL1 in H3122CR; D Effect of anlotinib treatment on chemokines expression in H3122 and H2228; E Anlotinib inhibited the JAK2/STAT3-VEGFA/IL6 axis. GAPDH served as a loading control. * p < 0.05, ** p < 0.01, *** p < 0.001, ns: not significant

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