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Table 3 Immune related pathways found to be significantly enriched in the tumors of female patients compared to tumors of male patients as computed by gene set enrichment analysis (GSEA; utilizing CIBERSORT gene sets) (NES: Normalized enrichment score)

From: Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males

Name

NES

p-val

FDR q-val

T_CELLS_GAMMA_DELTA

2.16

0.0052

0.1141

NK_CELLS_ACTIVATED

1.97

0.0102

0.0607

NK_CELLS_RESTING

1.77

0.0118

0.0552

DENDRITIC_CELLS_ACTIVATED

1.73

0.0106

0.0465

T_CELLS_REGULATORY_(TREGS)

1.65

0.0085

0.0503

DENDRITIC_CELLS_RESTING

1.59

0.0140

0.0636

T_CELLS_CD8

1.52

0.0270

0.0830

MACROPHAGES_M1

1.50

0.0164

0.0824

T_CELLS_CD4_NAIVE

1.46

0.0294

0.0932