Fig. 7

DLEU1 depletion sensitizes ESCC cells to cisplatin-induced death. A Dose–response curves of KYSE-410 cells to cisplatin after DLEU1 knockdown. B Schematic diagram showing the experimental strategy (n = 6 per group). C Tumor volume of the ESCC xenografts was measured. Significance was determined by two-way ANOVA with Tukey’s post-hoc test. *P < 0.05, **P < 0.01, ***P < 0.001. D Tumors were excised from nude mice at the end of the experiment. E Representative immunohistochemical staining of DYNLL1 and BCL2 proteins in DLEU1-silencing ESCC xenografts. Scale bar, 50 μm. F Graphical abstract illustrating the mechanism by which DLEU1 stabilizes DYNLL1 and promotes cell survival in ESCC